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Acurx Pharmaceuticals: Diving into Phase 2 Results and the Impact on Stock Performance

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In recent news, Acurx Pharmaceuticals Inc (NASDAQ: ACXP) made an announcement regarding the efficacy results from their Phase 2 trial, causing a significant decline in their stock price. Let’s take a closer look at the trial results and how they have affected investor sentiment.

The Phase 2 Trial and Key Findings

Acurx Pharmaceuticals, a biotech company, recently terminated the Phase 2b vancomycin-controlled trial segment early. The decision was influenced by factors such as the high observed clinical cure rate, the absence of emerging safety concerns, and the challenges faced due to the COVID-19 pandemic.

Aggregate blinded data revealed a high clinical cure rate for the treatment of C. difficile Infection (CDI), with no safety concerns noted. It was projected that the clinical cure rate for ibezapolstat, the drug being tested, would be at least 90% pooled across the open-label Phase 2a and the blinded Phase 2b segments.

The overall observed Clinical Cure rate in the combined Phase 2 trials in patients with CDI was an impressive 96%. Out of 26 patients, 25 achieved clinical cure, including 10 out of 10 patients (100%) in Phase 2a and 15 out of 16 patients (94%) in Phase 2b.

Investor Reaction and Stock Performance

Despite the positive trial results, Acurx Pharmaceuticals saw a sharp decline in its stock price. As of the latest update, ACXP shares have dropped more than 31%, trading at $3.48. This decline can be attributed to various factors, including market uncertainties and investor reactions to the trial’s early termination.

CEO’s Perspective and Future Plans

Acurx Pharmaceuticals’ CEO, David Luci, remains optimistic about the potential of ibezapolstat. He believes that the drug has a competitive advantage due to its high clinical cure rates, low recurrent infection rates, minimal disruption to the microbiome, and manufacturing efficiencies that allow for competitive pricing. As the company plans to enter Phase 3 pivotal clinical trials, they are optimistic about the drug’s prospects in front-line treatment of CDI.


Acurx Pharmaceuticals’ recent announcement regarding the termination of their Phase 2 trial segment has had a significant impact on their stock performance. While the trial results showcased impressive clinical cure rates and the absence of safety concerns, investor sentiment has contributed to the decline in stock price. However, the company’s CEO remains positive about the future prospects of their drug, ibezapolstat.

As with any investment decision, it is important for investors to conduct their own research and analysis. Stay tuned for further updates on Acurx Pharmaceuticals as they progress into Phase 3 pivotal clinical trials.

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