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Breakthrough Data Leads to Surge in MediciNova Stock Prices!

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MediciNova Inc’sΒ MNOV partners unveiled new data and findings from a Phase 2 clinical trial of MN-166 (ibudilast) in glioblastoma (GBM) patients at the Annual Meeting of theΒ Society for Neuro-Oncology.Β 

The primary objectives of this Phase 2 clinical trial were the safety and tolerability of MN-166 (ibudilast) and temozolomide (TMZ) combination treatment and the efficacy of the combination treatment defined as progression-free survival rate at six months using the RANO criteria.Β 

MN-166 (ibudilast) and TMZ combination treatment was safe and well-tolerated, and no unexpected adverse effects were reported.

The presentation also included data from preclinical studies that evaluated the combination of MN-166 (ibudilast) and anti-PD1 or anti-PD-L1 therapy in GBM models.

  • All subjects received TMZ and MN-166 (ibudilast) treatment. Progression-free survival at six months was 44% for new GBM and 31% for recurrent GBM.
  • CD3 expression was a good predictor for tumor progression at five months in recurrent glioblastoma subjects treated with MN-166 (ibudilast) and TMZ.

  • Median survival was extended to 66 days for the combination therapy of MN-166 (ibudilast) and anti-PD1 inhibitor treatment.
  • The addition of MN-166 (ibudilast) to the anti-PD-L1 inhibitor treatment significantly extended survival to a median of 34 days for the combination therapy.

Price Action:Β MNOV shares are up 14.3% at $2.04 on the last check Monday.

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