HomeMarket NewsMicro Cap StocksClene's Neurogenerative Candidate Shows Potential For Improved Long-Term Survival

Clene's Neurogenerative Candidate Shows Potential For Improved Long-Term Survival

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Clene Inc. (CLNN) Reports Positive Long-Term Data for CNM-Au8

Clene Inc. (CLNN) has released long-term follow-up data from the HEALEY ALS Platform Trial, which demonstrates the potential of their neurogenerative candidate, CNM-Au8, to improve the long-term survival of patients.

The post hoc analysis of the data shows a significant 49% decrease in the risk of death for patients treated with CNM-Au8 30mg for up to 133 weeks, compared to the largest U.S. clinical database of previous amyotrophic lateral sclerosis (ALS) trials, PRO-ACT.

ALS is a neurodegenerative disease that leads to the progressive degeneration of nerve cells in the spinal cord and brain.

A pooled analysis of the HEALEY ALS Platform Trial and the RESCUE-ALS Trial demonstrated a statistically significant 59% decrease in the risk of death for patients originally randomized to CNM-Au8 30mg (n=82) compared to PRO-ACT matched placebo patients during long-term follow-up.

No serious adverse events related to CNM-Au8 treatment have been reported, and the adverse events observed were predominantly mild-to-moderate in severity and transient in nature.

In addition, Clene previously reported that CNM-Au8 treatment resulted in a significant reduction in plasma neurofilament light chain (NfL) levels compared to placebo after 24 weeks in the HEALEY ALS Platform Trial.

The 24-month long-term data from the ongoing open-label extension (OLE) phase of the Phase 2 RESCUE-ALS trial showed a significant median survival benefit of 19.3 months and a 52% decrease in the risk of ALS clinical worsening events with CNM-Au8 treatment.

Price Action:Β On Monday, CLNN shares were up by 0.22% at $0.46.

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