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Why Is Cancer Firm Panbela Therapeutics Stock Trading Higher Today?

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Panbela Therapeutics IncΒ PBLA shares are trading higher after the company announced the publication of preclinical and clinical data from studies of CPP-1X (also known as Ξ±-Difluoromethylornithine (DFMO) or Eflornithine) in recent-onset type 1 diabetes (T1D).Β 

Data published in the journal Cell Reports Medicine investigated the mechanism of polyamines and polyamine inhibition by CPP-1X on Ξ² cell stress that plays a role in the onset of type 1 diabetes in in vitro and ex vivo models.Β 

Results showed that DFMO treatment may preserve Ξ² cell function, reflected by C-peptide levels in patients with T1D through the modulation of urinary polyamines, particularly putrescine.Β 

From the Phase 1 dose range finding study of CPP-1X in patients with recent onset T1D, CPP-1X was well tolerated, and a dose-dependent inhibition of ODC was observed.Β 

An exploratory secondary analysis showed that at the two highest dose levels, treatment with CPP-1X stabilized C-peptide areas under the curve compared to placebo.Β 

When assessing immune cell populations, there were no differences between the placebo and CPP-1X patients.

Results from these studies suggest that CPP-1X is a safe, oral treatment option that may improve Ξ² cell function and/or survival in recent onset T1D.

Price Action:Β PBLA shares are up 31.80% at $1.05 on the last check Thursday.

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