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The Bright Light of Real-World Evidence: CSL Seqirus Dazzles at OPTIONS XII Conference

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Real-World Evidence Shines

  • Real-world evidence (RWE) studies presented at OPTIONS XII showcase the efficacy of cell-based and MF59® adjuvanted influenza vaccines.
  • Evidence indicates enhanced relative vaccine effectiveness (rVE) of cell-based vaccines over egg-based ones in preventing test-confirmed influenza across various age groups, including children as young as six months.
  • Studies demonstrate the effectiveness of cell-based vaccines against medically attended, laboratory-confirmed influenza, with particular success in children aged six months to three years.
  • RWE studies have become integral in evaluating influenza vaccine effectiveness from season to season, adding to the wealth of data on real-world outcomes.

Given the ever-evolving nature of the influenza virus, the value of RWE studies in assessing vaccine effectiveness incrementally cannot be overstated. They complement the traditional randomized controlled trials, providing an ongoing assessment of the impact of influenza vaccines, thereby contributing to a robust collection of real-world outcomes.

Chief Health Officer of CSL Seqirus, Gregg Sylvester, emphasizes the company’s commitment to generating real-world evidence to evaluate vaccine effectiveness diligently. He mentions that their studies and presentations at OPTIONS XII underline their dedication to safeguarding individuals of all age groups, including infants as young as six months, against the perils of influenza and its associated complications. The choice to include studies with test-confirmed data is seen as a robust methodology that may produce more compelling evidence.

CSL Seqirus is showcasing various RWE studies at OPTIONS XII, each shedding light on different aspects of influenza prevention and its impact across different age groups.

Innovative Insights Unveiled

  • Results from the 2022/23 and 2023/24 influenza seasons in the US unveil the effectiveness of cell-based vaccines in preventing test-confirmed influenza.
  • Studies show higher effectiveness of cell-based quadrivalent vaccines compared to the egg-based versions for those aged six months to 64 years.
  • Data demonstrates the real-world effectiveness of cell culture-based vaccines against laboratory-confirmed influenza, particularly successful in children aged six months to three years.
  • Comparison of different vaccines over various influenza seasons reveals the superior efficacy of certain types in preventing both test-confirmed and clinically diagnosed influenza.
  • Studies also highlight the comparable effectiveness of MF59® adjuvanted vaccines and high-dose vaccines in preventing influenza-related emergency department visits and inpatient admissions among older adults.

Mendel Haag, Senior Director at CSL Seqirus, praises the continued value of RWE in offering critical insights into influenza vaccine effectiveness across different age groups. The studies presented capture data across recent influenza seasons, showcasing the prowess of cell-based vaccines in protecting against influenza, especially in vulnerable populations, and the balance between different vaccine types in preventing severe flu-related outcomes.

The research underscores CSL Seqirus’ unwavering commitment to advancing public health through the use of real-world evidence and cutting-edge vaccine technologies.

A Vision for Public Health

CSL Seqirus stands as a beacon in the realm of influenza research, proudly presenting an array of compelling data that addresses multiple facets of influenza prevention across diverse demographic segments.

The research profoundly reflects the company’s dedication to fostering public health through the application of real-world evidence and innovative vaccine solutions.

Key Takeaway

The studies shared at OPTIONS XII provide invaluable insights into the effectiveness of different influenza vaccines, particularly highlighting the success of cell-based options in safeguarding against the flu across various age groups. Through robust real-world evidence studies, CSL Seqirus continues to illuminate the path towards enhanced public health protection.

The Battle of Vaccines: Cell-Based vs. Egg-Based Influenza Vaccines

Discovering the Superiority of QIVc Over QIVe

Researchers revealed the superiority of QIVc over QIVe in preventing test-confirmed influenza during the 2022-23 season. A retrospective test-negative design was utilized, encompassing individuals aged 6 months to 64 years. The study showcased a higher effectiveness of 7.7% (95% CI: 0.9% – 13.9%) in outpatient care settings.

This revelation underscores a narrative of evolution in vaccine efficacy, mirroring the proverbial torch-passing from traditional egg-based vaccines to the innovative realm of cell-based vaccines. The study illuminates a shifting landscape in the fight against influenza, with cell-based vaccines emerging as the stalwart defenders.

The Consistent Advantage of QIVc Across Seasons

For individuals aged 4–64 years, a meta-analysis spanning multiple studies unveiled the consistent advantage of QIVc over QIVe/TIVe across three influenza seasons. The pooled relative vaccine effectiveness (rVE) figures revealed a persistent benefit, with estimates ranging from 10.0% to 18.7% in preventing various forms of influenza.

This unyielding advantage of QIVc paints a picture of reliability and steadfastness. Like a seasoned warrior, QIVc stands guard against the onslaught of influenza, ensuring protection for those within its realm.

The Triumph of ccIIV4 in Wisconsin

In the local arena of Wisconsin during the 2023-2024 flu season, ccIIV4 emerged victorious against medically attended, laboratory-confirmed influenza. The vaccine exhibited a commendable adjusted vaccine effectiveness (VE) of 60% (95% CI, 47%−70%) in individuals aged 6 months to 64 years.

The success of ccIIV4 in Wisconsin echoes a tale of resilience and adaptability. Like a hero rising to the occasion, ccIIV4 shields the vulnerable, especially children aged 6 months to 3 years, from the ravages of influenza.

The Parity Between aQIV and HD-QIV

A retrospective test-negative design study delved into the comparison between adjuvanted quadrivalent inactivated influenza vaccine (aQIV) and high-dose quadrivalent inactivated influenza vaccine (HD-QIV) in US adults aged ≥65 years during the 2022-2023 season. Surprisingly, no significant differences were found in the relative vaccine effectiveness (rVE) of the two vaccines in preventing test-confirmed influenza.

This parity between aQIV and HD-QIV symbolizes a balance of power, akin to a high-stakes chess match where each move is met with an equally formidable countermove. The study showcases a narrative of equilibrium in vaccine efficacy, highlighting the co-existence of multiple effective strategies in the battle against influenza.

Unveiling the Limitations

Despite the remarkable insights provided by these studies, it is crucial to acknowledge their inherent limitations. Residual confounding and the lack of random assignment in vaccine allocation pose challenges to the robustness of the findings. The presence of unmeasured variables and the absence of certain critical data underscore the complexities of real-world vaccine effectiveness assessments.

These limitations serve as a reminder that while the studies offer valuable insights, they are but a piece of the larger puzzle in understanding the true impact of different influenza vaccines. Like detectives unraveling a mystery, researchers must navigate through these limitations to uncover the complete narrative of vaccine effectiveness in the battle against influenza.

The Power of Influenza Prevention with CSL Seqirus

Delving into Seasonal Influenza

Every year, the looming threat of seasonal influenza grips the world in a briskly contagious embrace. With the potential to escalate into severe illness, influenza dances like a capricious suitor, offering anything from moderate respiratory conditions to life-threatening complications. This stealthy viral stalker can spread its misery before symptoms even come to light, leaving a trail of potential sickness in its wake. The CDC’s annual call to arms for vaccinations resonates as a clarion warning against this invisible marauder, urging individuals to fortify their defenses before influenza’s arrival.

Unveiling CSL Seqirus

Nestled within the mighty CSL conglomerate, CSL Seqirus emerges as a stalwart guardian against infectious maladies. Specializing in influenza vaccines, this global titan stands as a beacon of protection, equipped with cutting-edge facilities across the U.S., the U.K., and Australia. With a robust armor of R&D prowess, CSL Seqirus unfurls its banner across more than 20 nations, offering a diverse array of avant-garde influenza vaccines. A nexus of pandemic preparedness, this institution molds the future of public health with a blend of expertise and innovation that reverberates across continents.

The Saga of CSL

CSL, the progenitor of a biotechnological saga that began in the annals of 1916, casts its shadow over the realm of lifesaving medicine like a benevolent colossus. From hemophilia remedies to immune-boosting elixirs, CSL’s mantle of salvation extends far and wide, touching lives in over 100 nations. With a symphony of commercial acumen, research fervor, and operational excellence, CSL orchestrates miracles that pave the way for patients to savor the fullness of existence. A trifecta of CSL Behring, CSL Seqirus, and CSL Vifor stands as a testament to the unfaltering commitment to propelling biotechnological promises into reality.

Forecasting the Future with CSL Seqirus

In the realm of forward-looking parables, CSL Seqirus thrusts itself into the spotlight, donning the mantle of influenza defender with FLUCELVAX®. An incarnation of protection against the flu, FLUCELVAX® stands as a bulwark shielding individuals aged six months and beyond. As the guardian of health, FLUCELVAX® stands at the threshold, barring entry to those with a history of severe allergic reactions, a subtle reminder that not all shields are tailored for every warrior. Amidst the dance of unknown perils and untold triumphs, FLUCELVAX® carries the weight of hope, combating the flu with a vigor that echoes through the ages.

The symphony of FLUCELVAX® beckons to the wary, offering a shield against the unseen foes that lurk in the shadows of coughs and sniffles. As individuals prepare to roll up their sleeves in the face of influenza’s annual dance, the story of CSL Seqirus unfolds like a saga of resilience, innovation, and unwavering commitment to safeguarding the tapestry of human health.



Celebrating the Effectiveness of Influenza Vaccinations

The Shield Against Influenza

The recent presentation of real-world evidence by CSL Seqirus at the Options XII Conference has shone a light on the efficacy of influenza vaccinations. This unveiling underscores the vital role that vaccines play in safeguarding individuals against the seasonal flu, making a significant contribution to public health.

Unveiling the Armour of Protection

Debunking any doubts surrounding the potency of influenza vaccines, CSL Seqirus’ data showcase the tangible benefits of these preventive measures. The findings not only validate the effectiveness of vaccinations but also reinforce the importance of widespread inoculation in curbing the spread of infectious diseases.

Empowering Through Prevention

As we navigate through a landscape where health and safety are paramount, the revelations presented by CSL Seqirus offer a beacon of hope. By illustrating the tangible impact of influenza vaccinations, individuals are empowered to make informed decisions regarding their well-being, taking proactive steps to protect themselves and those around them.

An Ode to Resilience

Looking back at historical benchmarks, the evolution of vaccines has been instrumental in combating infectious diseases and enhancing public health outcomes. Today, as we traverse the complexities of healthcare challenges, the efficacy of influenza vaccinations stands as a testament to our resilience as a society, armed with the tools to fortify our immune systems and shield against seasonal threats.


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